Short answer:
1/2048 here is the highest possible natural (i.e. not taking time bomb into account) relative difficulty increase for a block with no uncles. For a block with uncles this number is twice as high: 1/1024. So if previous block had difficulty of x, then current block will have difficulty of at most x + x/2048, in case current block doesn't have any uncles, and x + x/1024 if it does have.
Long answer:
Let's explain the notation used in the yellow paper:
D_0: Difficulty of the first block and minimum possible difficulty for any other block (131072)
H: Header of current block
P(H): Parent block of H
P(H)_{H_d}: Parent block difficulty
x: Maximum possible absolute difficulty increase in case current block has no uncles (P(H)_{H_d} / 2048)
\varsigma_2: Difficulty change factor [-99 .. +2]
\epsilon: Difficulty bomb addition
y: Maximum possible difficulty change factor (1 if current block has no uncles, 2 otherwise)
H_s: Current block timestamp in seconds
P(H)_{H_s}: Parent block timestamp seconds
9: Target block mining time in seconds
-99: Minimum possible difficulty change factor
So, basically, for block with no uncles, difficulty change factor is 1 - t / 9, where t is the mining time of current block. If mining time is exactly 9 seconds, change factor will be zero. If mining time is less than one, then change factor is positive, i.e. difficulty increases when blocks are being mined too fast. If mining time is greater than 9, then change factor is negative, thus difficulty decreases when blocks are being mined too slow.
For blocks with uncles, difficulty change factor is 2 - t / 9, so “neutral” mining time is 18 seconds. Thus, if many blocks have uncles, then block mining time will drift towards 18 seconds, while if there are few blocks with uncles, it will drift towards 9 seconds.
Difficulty change factor is that multiplied by x, i.e. by the difficulty of the parent block divided by 2048. So in case difficulty change factor is +1, then the dificculty will be changed by 1/2048 of the part block's difficulty.