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TL;DR - Ganache and Puppeth are both tools to spin up your own blockchain. Ganache is meant to be used as a testbed where transactions can be created and contracts can be deployed freely and instantaneously. Puppeth is similar in that it has the ability to do this as well. Puppeth has the advantage of being more configurable and acting more similar to a live ...
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From a recent issue on Sep 16th, 2019:
ganache-core does not currently support a mempool, although this WIP refactor by @davidmurdoch does support a mempool to some degree
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