As far as I understand EthereumJS can simulate a client on a simulated blockchain and provide RPC interface (hope I'm using the right words). Does it mean I can interact with this client (and with my contract in simulated blockchain) with ethjsonrpc?


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Yes since testrpc provides exactly a Remote Procedure Call interface you can use EthJsonRpc as a client library to interface with the simulated blockchain.
Just fire up testrpc in a console and it should work. I use testrpc together with truffle and it should be no different for a Python based client.


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